It's not always clear what causes mouth cancer but it can happen when cells on the lips or in the mouth develop changes in their DNA. These cancerous cells might form a mass known as a tumor that can grow to invade and harm healthy body tissue.
Here are some risk factors:
1. Use of Tobacco (Smoking or Chewing)
Chemicals present in tobacco can damage the mouth cells' DNA directly. This can lead to mutations that may turn normal cells cancerous over time.
2. Excessive Consumption of Alcohol
Alcohol breaks down into acetaldehyde, a toxic chemical that damages cell DNA. Over time, it makes oral cells more permeable to other carcinogens (like those present in tobacco), causing cell damage and unregulated growth.
Additionally, alcohol increases levels of hormones such as estrogen and insulin, which can support faster cell division.
3. Combined Use of Tobacco & Alcohol
The risk of mouth cancer is dramatically higher when alcohol is taken in combination with tobacco. Together, they weaken mouth defenses, allowing carcinogens to penetrate deeper and speed up the growth of cancerous cells.
4. HPV Infection (Particularly Type 16)
HPV-16 inserts its DNA into the mouth cells. This disrupts the normal cell growth regulators that trigger uncontrolled division.
5. Betel Nut or Paan Chewing
Betel nut (areca nut) chewing introduces carcinogens like nitrosamines in the mouth, which damage DNA. This is very common in high-risk areas like India.
6. Exposure to Excessive Sunlight
Ultraviolet (UV) radiation from excessive sun exposure penetrates the delicate skin on the lips. This can damage cell DNA, leading to mutations and uncontrolled cell growth.
7. Diet Low in Fruits and Veggies
A poor diet lacks antioxidants that repair DNA damage due to many factors. This allows cancer-causing changes in the mouth.
8. Poor Health of the Immune System
Low immunity fails to destroy early damaged cells. This lets them multiply into unchecked tumors.
Other Contributing Factors of Oral Cancer
- Poor oral hygiene
- Age and gender (most cases occur after age 40, and men are at a higher risk)
- Genetics predisposition
Read Also: The Fight Against Lung Cancer: Early Detection and Prevention